Cryptochromatic Spectacles are a special pair of glasses added to Fallout 3 in the fourth DLC pack; Point Lookout. There's only one pair in the game and they're found in the toilet tank of room 1D in the The Homestead Motel.
 The Velvet Curtain
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These glasses are an important part of the quest as they will help you see rings that are hidden to the naked eye. Those rings will help you activate a hidden bunker, which contains the Backwater Rifle.